Overview

Location [1]
6p21.1
Pathway
Cell cycle control
Protein [2]
G1/S-specific cyclin-D3
Synonyms [1]
-

Cyclin D3 (CCND3) is a gene that encodes a protein that functions in the regulation of CDK kinases in the cell cycle. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, skin cancer, and stomach cancer.

CCND3 is altered in 1.06% of all cancers with breast carcinoma, non-small cell lung carcinoma, colorectal adenocarcinoma, lymphoma, and sarcoma having the greatest prevalence of alterations [3].

CCND3 GENIE Cases - Top Diseases

The most common alterations in CCND3 are CCND3 Amplification (0.58%), CCND3 Mutation (0.52%), CCND3 R271Pfs*53 (0.03%), CCND3 Loss (0.02%), and CCND3 Q276* (0.02%) [3].

CCND3 GENIE Cases - Top Alterations

Significance of CCND3 in Diseases

Malignant Solid Tumor +

Multiple Myeloma +

Non-Hodgkin Lymphoma +

Breast Carcinoma +

Lymphoma +

Gastric Carcinoma +

Esophageal Carcinoma +

Colorectal Carcinoma +

Squamous Cell Lung Carcinoma +

Cancer +

Germ Cell Tumor +

Histiocytic And Dendritic Cell Neoplasm +

Plasma Cell Leukemia +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.