Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
T-cell-specific surface glycoprotein CD28
Synonyms [1]

CD28 is altered in 0.17% of all cancers with acute myeloid leukemia with t(6;9) (p23;q34.1); DEK-NUP214, peripheral T-cell lymphoma, not otherwise specified, acute myeloid leukemia, Burkitt lymphoma, and sezary syndrome having the greatest prevalence of alterations [3].

CD28 GENIE Cases - Top Diseases

The most common alterations in CD28 are CD28 Mutation (0.09%), CD28 Amplification (0.07%), CD28 K81E (0.05%), CD28 A31V (0.02%), and CD28 Q25L (0.02%) [3].

CD28 GENIE Cases - Top Alterations

Significance of CD28 in Diseases

Multiple Myeloma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.