Location [1]
Immune checkpoints
Protein [2]
B-cell antigen receptor complex-associated protein beta chain
Synonyms [1]
IGB, AGM6, B29

CD79b molecule, immunoglobulin-associated beta (CD79B) is a gene that encodes the Ig-beta protein. The protein functions as a component of the B-cell antigen that is a member of the B lymphocyte antigen receptor multimeric protein complex. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as hematopoietic and lymphoid cancers, intestinal cancer, and lung cancer.

CD79B is altered in 1.09% of all cancers with breast invasive ductal carcinoma, diffuse large B-cell lymphoma, not otherwise specified, invasive breast carcinoma, lung adenocarcinoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

CD79B GENIE Cases - Top Diseases

The most common alterations in CD79B are CD79B Amplification (0.62%), CD79B Mutation (0.44%), CD79B Loss (0.07%), CD79B Y196H (0.04%), and CD79B X183_splice (0.04%) [3].

CD79B GENIE Cases - Top Alterations

Significance of CD79B in Diseases

Diffuse Large B-Cell Lymphoma +

Mycosis Fungoides +

Cervical Carcinoma +

Cancer +

Head And Neck Squamous Cell Carcinoma +

Adult T-Cell Acute Lymphoblastic Leukemia +

Anaplastic Large Cell Lymphoma +

Angioimmunoblastic T-Cell Lymphoma +

Enteropathy-Associated T-Cell Lymphoma +

Follicular T-Cell Lymphoma +

Hepatosplenic T-Cell Lymphoma +

Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma +

Nasal Type Extranodal NK/T-Cell Lymphoma +

Nodal Peripheral T-Cell Lymphoma With TFH Phenotype +

Peripheral T-Cell Lymphoma +

Peripheral T-Cell Lymphoma, Not Otherwise Specified +

Primary Cutaneous T-Cell Non-Hodgkin Lymphoma +

Sezary Syndrome +

Subcutaneous Panniculitis-Like T-Cell Lymphoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.