Location [1]
Xp22.33 and Yp11.2
JAK/STAT signaling
Protein [2]
Cytokine receptor-like factor 2
Synonyms [1]

CRLF2 (cytokine receptor-like factor 2) is a gene that encodes for the protein cytokine receptor-like factor 2, a receptor protein that participates in activating STAT (signal transducer and activator of transcription) signaling. In cancer, CRLF2 rearrangements and one recurring mutation leading to CRLF2 overexpression have been identified in a subset of patients with high risk acute lymphoblastic leukemia who have an exceptionally dismal prognosis.

CRLF2 is altered in 0.80% of all cancers with lung adenocarcinoma, cutaneous melanoma, colon adenocarcinoma, high grade ovarian serous adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

CRLF2 GENIE Cases - Top Diseases

The most common alterations in CRLF2 are CRLF2 Loss (0.49%), CRLF2 Mutation (0.31%), CRLF2 Amplification (0.11%), CRLF2 R3W (0.01%), and CRLF2 S128L (0.01%) [3].

CRLF2 GENIE Cases - Top Alterations

Significance of CRLF2 in Diseases

Acute Lymphoblastic Leukemia +

B-Cell Acute Lymphoblastic Leukemia +

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

B-Cell Lymphoblastic Leukemia/Lymphoma +

Chronic Myeloid Leukemia +

Chronic Myelomonocytic Leukemia +

Mixed Phenotype Acute Leukemia +

Secondary Acute Myeloid Leukemia +

T-Cell Lymphoblastic Leukemia/Lymphoma +

Therapy-Related Acute Myeloid Leukemia +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.