Overview

Location [1]
1q23.3
Pathway
Receptor tyrosine kinase/growth factor signaling
Synonyms [1]
TYRO10, TKT, WRCN, MIG20a, NTRKR3

DDR2 (discoidin domain receptor tyrosine kinase 2) is a gene that encodes the discoidin domain-containing receptor 2 protein, a tyrosine kinase. Binding of collagen to DDR2 results in activation of downstream signaling pathways, perhaps the SRC and STAT signaling pathways. Similar to integrin receptors, DDR2 may play a role in modulating cellular interactions with the extracellular matrix.

 

Significance of DDR2 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Esophageal Carcinoma +

Gastric Carcinoma +

Gastrointestinal Stromal Tumor +

Head And Neck Squamous Cell Carcinoma +

Hepatobiliary Neoplasm +

Lip And Oral Cavity Carcinoma +

Lymphoma +

Malignant Hepatobiliary Neoplasm +

Malignant Laryngeal Neoplasm +

Malignant Salivary Gland Neoplasm +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Oropharyngeal Carcinoma +

Pancreatic Carcinoma +

Urothelial Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.