Overview

Location [1]
1q23.3
Pathway
Receptor tyrosine kinase/growth factor signaling
Protein [2]
Discoidin domain-containing receptor 2
Synonyms [1]
TYRO10, MIG20a, NTRKR3, TKT

DDR2 (discoidin domain receptor tyrosine kinase 2) is a gene that encodes the discoidin domain-containing receptor 2 protein, a tyrosine kinase. Binding of collagen to DDR2 results in activation of downstream signaling pathways, perhaps the SRC and STAT signaling pathways. Similar to integrin receptors, DDR2 may play a role in modulating cellular interactions with the extracellular matrix.

 

DDR2 is altered in 1.84% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

DDR2 GENIE Cases - Top Diseases

The most common alterations in DDR2 are DDR2 Mutation (1.72%), DDR2 Amplification (0.52%), DDR2 I488M (0.02%), DDR2 R668H (0.02%), and DDR2 R105C (0.02%) [3].

DDR2 GENIE Cases - Top Alterations

Significance of DDR2 in Diseases

Non-Small Cell Lung Carcinoma +

Malignant Solid Tumor +

Urothelial Carcinoma +

Esophageal Carcinoma +

Lymphoma +

Gastric Carcinoma +

Hepatobiliary Neoplasm +

Malignant Hepatobiliary Neoplasm +

Pancreatic Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Gastrointestinal Stromal Tumor +

Head And Neck Squamous Cell Carcinoma +

Lip And Oral Cavity Carcinoma +

Malignant Laryngeal Neoplasm +

Malignant Salivary Gland Neoplasm +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Oropharyngeal Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.