Overview

Location [1]
12q13.2
Pathway
Receptor tyrosine kinase/growth factor signaling
Synonyms [1]
p180-ErbB3, c-erbB3, c-erbB-3, LCCS2, MDA-BF-1, p45-sErbB3, FERLK, erbB3-S, HER3, ErbB-3, p85-sErbB3

Erb-b2 receptor tyrosine kinase 3 (ERBB3) is a gene that encodes a receptor tyrosine kinase in the epidermal growth factor family. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

Significance of ERBB3 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Breast Carcinoma +

Colorectal Carcinoma +

Bladder Carcinoma +

Melanoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Cervical Carcinoma +

Gastric Carcinoma +

Head And Neck Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Hepatocellular Carcinoma +

Urothelial Carcinoma +

Anaplastic Astrocytoma +

Bile Duct Carcinoma +

Biliary Tract Neoplasm +

Bronchogenic Carcinoma +

Endometrial Carcinoma +

Esophageal Squamous Cell Carcinoma +

Gallbladder Carcinoma +

Gastric Adenocarcinoma +

Glioblastoma +

Lung Carcinoma +

Lymphoma +

Malignant Uterine Neoplasm +

Pancreatic Adenocarcinoma +

Prostate Carcinoma +

Sarcoma +

Soft Tissue Sarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.