Location [1]
Receptor tyrosine kinase/growth factor signaling
Protein [2]
Fibroblast growth factor 10
Synonyms [1]

Fibroblast growth factor 10 (FGF10) is a gene that encodes a protein with mitogenic activity that functions in the keratinization of epidermal cells. Missense mutations, nonsense mutations, silent mutations, and in-frame deletions are observed in cancers such as intestinal cancer, lung cancer, and skin cancer.

FGF10 is altered in 1.23% of all cancers with melanoma, colon adenocarcinoma, breast invasive ductal carcinoma, cutaneous melanoma, and lung adenocarcinoma having the greatest prevalence of alterations [3].

FGF10 GENIE Cases - Top Diseases

The most common alterations in FGF10 are FGF10 Mutation (0.71%), FGF10 Amplification (1.78%), FGF10 V123I (0.15%), FGF10 E158K (0.09%), and FGF10 R193Q (0.20%) [3].

FGF10 GENIE Cases - Top Alterations

Significance of FGF10 in Diseases

Urothelial Carcinoma +

Gastric Carcinoma +

Endometrial Carcinoma +

Malignant Solid Tumor +

Cancer +

Squamous Cell Lung Carcinoma +

Cholangiocarcinoma +

Multiple Myeloma +

Myeloproliferative Neoplasm +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.