Overview

Location [1]
5p12
Pathway
Receptor tyrosine kinase/growth factor signaling
Protein [2]
Fibroblast growth factor 10
Synonyms [1]
-

Fibroblast growth factor 10 (FGF10) is a gene that encodes a protein with mitogenic activity that functions in the keratinization of epidermal cells. Missense mutations, nonsense mutations, silent mutations, and in-frame deletions are observed in cancers such as intestinal cancer, lung cancer, and skin cancer.

FGF10 is altered in 1.82% of all cancers with melanoma, non-small cell lung carcinoma, breast carcinoma, ovarian neoplasm, and bladder carcinoma having the greatest prevalence of alterations [3].

FGF10 GENIE Cases - Top Diseases

The most common alterations in FGF10 are FGF10 Amplification (0.07%), FGF10 Mutation (0.04%), FGF10 C23del (0.00%), FGF10 E158K (0.00%), and FGF10 E112K (0.00%) [3].

FGF10 GENIE Cases - Top Alterations

Significance of FGF10 in Diseases

Urothelial Carcinoma +

Malignant Solid Tumor +

Multiple Myeloma +

Myeloproliferative Neoplasm +

Gastric Carcinoma +

Anaplastic Astrocytoma +

Squamous Cell Lung Carcinoma +

Anaplastic Oligodendroglioma +

Cancer +

Endometrial Carcinoma +

Extrahepatic Cholangiocarcinoma +

Glioblastoma +

Intrahepatic Cholangiocarcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.