Overview

Location [1]
3q28-q29
Protein [2]
Fibroblast growth factor 12
Synonyms [1]
EIEE47, FGF12B, FHF1

FGF12 is altered in 0.02% of all cancers with adrenal cortex carcinoma, breast invasive ductal carcinoma, colorectal adenocarcinoma, head and neck squamous cell carcinoma, and pancreatic adenocarcinoma having the greatest prevalence of alterations [3].

FGF12 GENIE Cases - Top Diseases

The most common alterations in FGF12 are FGF12 Mutation (1.04%), FGF12 D102N (2.08%), FGF12 G120R (2.08%), FGF12 Loss (0.30%), and FGF12 Q12K (0.30%) [3].

FGF12 GENIE Cases - Top Alterations

Significance of FGF12 in Diseases

Urothelial Carcinoma +

Malignant Solid Tumor +

Multiple Myeloma +

Cancer +

Anaplastic Astrocytoma +

Anaplastic Oligodendroglioma +

Cholangiocarcinoma +

Endometrial Carcinoma +

Extrahepatic Cholangiocarcinoma +

Gastric Carcinoma +

Glioblastoma +

Intrahepatic Cholangiocarcinoma +

Myeloproliferative Neoplasm +

Squamous Cell Lung Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.