Overview

Location [1]
13q33.1
Pathway
Receptor tyrosine kinase/growth factor signaling
Protein [2]
Fibroblast growth factor 14
Synonyms [1]
FGF-14, SCA27, FHF4, FHF-4

Fibroblast growth factor 14 (FGF14) is a gene that encodes a protein with mitogenic activity that functions in embryonic development and cell growth. Missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, lung cancer, and intestinal cancer.

FGF14 is altered in 0.38% of all cancers with colon adenocarcinoma, cutaneous melanoma, rectal adenocarcinoma, lung adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

FGF14 GENIE Cases - Top Diseases

The most common alterations in FGF14 are FGF14 Mutation (1.04%), FGF14 Amplification (1.62%), FGF14 A231V (0.09%), FGF14 E147* (0.15%), and FGF14 D92N (0.11%) [3].

FGF14 GENIE Cases - Top Alterations

Significance of FGF14 in Diseases

Urothelial Carcinoma +

Malignant Solid Tumor +

Multiple Myeloma +

Squamous Cell Lung Carcinoma +

Gastric Carcinoma +

Anaplastic Astrocytoma +

Cancer +

Endometrial Carcinoma +

Glioblastoma +

Anaplastic Oligodendroglioma +

Cholangiocarcinoma +

Extrahepatic Cholangiocarcinoma +

Intrahepatic Cholangiocarcinoma +

Myeloproliferative Neoplasm +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.