Overview

Location [1]
13q33.1
Pathway
Receptor tyrosine kinase/growth factor signaling
Synonyms [1]
SCA27, FHF4, FGF-14, FHF-4

Fibroblast growth factor 14 (FGF14) is a gene that encodes a protein with mitogenic activity that functions in embryonic development and cell growth. Missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, lung cancer, and intestinal cancer.

Significance of FGF14 in Diseases

Urothelial Carcinoma +

Cancer +

Cholangiocarcinoma +

Endometrial Carcinoma +

Gastric Carcinoma +

Malignant Solid Tumor +

Multiple Myeloma +

Myeloproliferative Neoplasm +

Squamous Cell Lung Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.