Overview

Location [1]
11q13.3
Pathway
Receptor tyrosine kinase/growth factor signaling
Protein [2]
Fibroblast growth factor 3
Synonyms [1]
HBGF-3, INT2

Fibroblast growth factor 3 (FGF3) is a gene that encodes a protein with mitogenic activity that functions in embryonic development and cell growth. Missense mutations, silent mutations, and frameshift insertions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

FGF3 is altered in 4.81% of all cancers with breast carcinoma, non-small cell lung carcinoma, melanoma, bladder carcinoma, and head and neck squamous cell carcinoma having the greatest prevalence of alterations [3].

FGF3 GENIE Cases - Top Diseases

The most common alterations in FGF3 are FGF3 Amplification (2.53%), FGF3 Mutation (0.36%), FGF3 Loss (0.03%), FGF3 R181H (0.01%), and FGF3 E189K (0.01%) [3].

FGF3 GENIE Cases - Top Alterations

Significance of FGF3 in Diseases

Urothelial Carcinoma +

Malignant Solid Tumor +

Multiple Myeloma +

Squamous Cell Lung Carcinoma +

Gastric Carcinoma +

Intrahepatic Cholangiocarcinoma +

Endometrial Carcinoma +

Anaplastic Oligodendroglioma +

Glioblastoma +

Anaplastic Astrocytoma +

Cancer +

Diffuse Intrinsic Pontine Glioma +

Extrahepatic Cholangiocarcinoma +

Glioma +

Myeloproliferative Neoplasm +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.