Overview

Location [1]
11q13.3
Pathway
Receptor tyrosine kinase/growth factor signaling
Synonyms [1]
HST-1, HST, K-FGF, HBGF-4, HSTF1, FGF-4, HSTF-1, KFGF

Fibroblast growth factor 4 (FGF4) is a gene that encodes a protein with mitogenic activity that functions in embryonic development and cell growth. Missense, nonsense, and silent mutations are observed in cancers such as intestinal cancer, ovarian cancer, and skin cancer.

Significance of FGF4 in Diseases

Urothelial Carcinoma +

Cholangiocarcinoma +

Malignant Solid Tumor +

Cancer +

Endometrial Carcinoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Hepatocellular Carcinoma +

Multiple Myeloma +

Myeloproliferative Neoplasm +

Nasopharyngeal Carcinoma +

Ovarian Carcinoma +

Squamous Cell Lung Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.