Overview

Location [1]
11q13.3
Pathway
Receptor tyrosine kinase/growth factor signaling
Protein [2]
Fibroblast growth factor 4
Synonyms [1]
HST, HSTF1, HST-1, K-FGF, HBGF-4, KFGF

Fibroblast growth factor 4 (FGF4) is a gene that encodes a protein with mitogenic activity that functions in embryonic development and cell growth. Missense, nonsense, and silent mutations are observed in cancers such as intestinal cancer, ovarian cancer, and skin cancer.

FGF4 is altered in 4.72% of all cancers with breast carcinoma, non-small cell lung carcinoma, bladder carcinoma, melanoma, and head and neck squamous cell carcinoma having the greatest prevalence of alterations [3].

FGF4 GENIE Cases - Top Diseases

The most common alterations in FGF4 are FGF4 Amplification (2.60%), FGF4 Mutation (0.24%), FGF4 Loss (0.03%), FGF4 A52V (0.01%), and FGF4 G190R (0.01%) [3].

FGF4 GENIE Cases - Top Alterations

Significance of FGF4 in Diseases

Urothelial Carcinoma +

Malignant Solid Tumor +

Multiple Myeloma +

Esophageal Carcinoma +

Nasopharyngeal Carcinoma +

Squamous Cell Lung Carcinoma +

Hepatocellular Carcinoma +

Gastric Carcinoma +

Cholangiocarcinoma +

Intrahepatic Cholangiocarcinoma +

Endometrial Carcinoma +

Glioblastoma +

Anaplastic Astrocytoma +

Anaplastic Oligodendroglioma +

Cancer +

Extrahepatic Cholangiocarcinoma +

Myeloproliferative Neoplasm +

Ovarian Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.