Overview

Location [1]
12p13.32
Pathway
Receptor tyrosine kinase/growth factor signaling
Protein [2]
Fibroblast growth factor 6
Synonyms [1]
HBGF-6, HST2

Fibroblast growth factor 6 (FGF6) is a gene that encodes a protein with mitogenic activity that functions in embryonic development and cell growth. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

FGF6 is altered in 2.13% of all cancers with melanoma, colorectal adenocarcinoma, breast carcinoma, non-small cell lung carcinoma, and malignant glioma having the greatest prevalence of alterations [3].

FGF6 GENIE Cases - Top Diseases

The most common alterations in FGF6 are FGF6 Mutation (0.07%), FGF6 Amplification (0.06%), FGF6 G187R (0.00%), FGF6 R125Q (0.00%), and FGF6 R188W (0.00%) [3].

FGF6 GENIE Cases - Top Alterations

Significance of FGF6 in Diseases

Urothelial Carcinoma +

Malignant Solid Tumor +

Multiple Myeloma +

Anaplastic Astrocytoma +

Squamous Cell Lung Carcinoma +

Intrahepatic Cholangiocarcinoma +

Glioblastoma +

Anaplastic Oligodendroglioma +

Cancer +

Endometrial Carcinoma +

Extrahepatic Cholangiocarcinoma +

Gastric Carcinoma +

Myeloproliferative Neoplasm +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.