Overview

Location [1]
13q12.3
Pathway
Receptor tyrosine kinase/growth factor signaling
Protein [2]
Vascular endothelial growth factor receptor 1
Synonyms [1]
VEGFR1, FLT, FLT-1, VEGFR-1

Fms-related tyrosine kinase 1 (FLT1) is a gene that encodes a protein that is a receptor tyrosine kinase in the vascular endothelial growth factor receptor (VEGF) family. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

FLT1 is altered in 2.71% of all cancers with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, breast invasive ductal carcinoma, and melanoma having the greatest prevalence of alterations [3].

FLT1 GENIE Cases - Top Diseases

The most common alterations in FLT1 are FLT1 Mutation (2.78%), FLT1 Missense (2.56%), FLT1 Amplification (0.39%), FLT1 Nonsense (0.16%), and FLT1 Frameshift (0.11%) [3].

FLT1 GENIE Cases - Top Alterations

Significance of FLT1 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Esophageal Carcinoma +

Pancreatic Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Melanoma +

Lung Carcinoma +

Malignant Uterine Neoplasm +

Colorectal Carcinoma +

Cervical Carcinoma +

Urothelial Carcinoma +

Bladder Carcinoma +

Cancer +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Ovarian Carcinoma +

Malignant Hepatobiliary Neoplasm +

Hepatobiliary Neoplasm +

Bile Duct Carcinoma +

Breast Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Lymphoma +

Acute Lymphoblastic Leukemia +

Acute Myeloid Leukemia +

Bronchogenic Carcinoma +

Chronic Myeloid Leukemia +

Esophageal Squamous Cell Carcinoma +

Gallbladder Carcinoma +

Gastrointestinal Stromal Tumor +

Head And Neck Carcinoma +

Leukemia +

Lip And Oral Cavity Carcinoma +

Malignant Laryngeal Neoplasm +

Malignant Salivary Gland Neoplasm +

Multiple Myeloma +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Oropharyngeal Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.