Overview

Location [1]
5q35.3
Pathway
Receptor tyrosine kinase/growth factor signaling
Protein [2]
Vascular endothelial growth factor receptor 3
Synonyms [1]
FLT41, VEGFR3, PCL, LMPH1A, VEGFR-3, FLT-4

Fms-related tyrosine kinase 4 (FLT4) is a gene that encodes a protein that is a receptor tyrosine kinase in the vascular endothelial growth factor receptor (VEGF) family. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

FLT4 is altered in 2.73% of all cancers with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, breast invasive ductal carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

FLT4 GENIE Cases - Top Diseases

The most common alterations in FLT4 are FLT4 Mutation (3.01%), FLT4 Missense (2.75%), FLT4 Frameshift (0.17%), FLT4 Nonsense (0.11%), and FLT4 Loss (0.09%) [3].

FLT4 GENIE Cases - Top Alterations

Significance of FLT4 in Diseases

Non-Small Cell Lung Carcinoma +

Malignant Solid Tumor +

Esophageal Carcinoma +

Pancreatic Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Melanoma +

Colorectal Carcinoma +

Malignant Uterine Neoplasm +

Lung Carcinoma +

Cancer +

Gastric Adenocarcinoma +

Gastric Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Urothelial Carcinoma +

Bladder Carcinoma +

Hepatobiliary Neoplasm +

Malignant Hepatobiliary Neoplasm +

Bile Duct Carcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Gastrointestinal Stromal Tumor +

Bronchogenic Carcinoma +

Cervical Carcinoma +

Esophageal Squamous Cell Carcinoma +

Gallbladder Carcinoma +

Head And Neck Carcinoma +

Lip And Oral Cavity Carcinoma +

Malignant Laryngeal Neoplasm +

Malignant Salivary Gland Neoplasm +

Multiple Myeloma +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Oropharyngeal Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.