Overview

Location [1]
5q35.3
Pathway
Receptor tyrosine kinase/growth factor signaling
Synonyms [1]
PCL, LMPH1A, VEGFR3, FLT-4, VEGFR-3, FLT41, LMPHM1, CHTD7

Fms-related tyrosine kinase 4 (FLT4) is a gene that encodes a protein that is a receptor tyrosine kinase in the vascular endothelial growth factor receptor (VEGF) family. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

Significance of FLT4 in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Pancreatic Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Bile Duct Carcinoma +

Bladder Carcinoma +

Breast Carcinoma +

Bronchogenic Carcinoma +

Cancer +

Cervical Carcinoma +

Colorectal Carcinoma +

Esophageal Carcinoma +

Esophageal Squamous Cell Carcinoma +

Gallbladder Carcinoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Gastrointestinal Stromal Tumor +

Head And Neck Carcinoma +

Hepatobiliary Neoplasm +

Lip And Oral Cavity Carcinoma +

Lung Carcinoma +

Malignant Hepatobiliary Neoplasm +

Malignant Laryngeal Neoplasm +

Malignant Salivary Gland Neoplasm +

Malignant Uterine Neoplasm +

Melanoma +

Multiple Myeloma +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Oropharyngeal Carcinoma +

Ovarian Carcinoma +

Prostate Carcinoma +

Soft Tissue Sarcoma +

Urothelial Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.