Overview

Location [1]
19p13.3
Pathway
G-protein signaling
Protein [2]
Guanine nucleotide-binding protein subunit alpha-11
Synonyms [1]
HYPOC2, FHH2, GNA-11, HHC2, FBH2, FBH

GNA11 (guanine nucleotide binding protein (G protein), alpha 11 (Gq class)) is a gene that encodes the guanine nucleotide-binding protein subunit alpha-11, a subunit of one of the heterotrimeric guanine nucleotide binding proteins (G proteins). Oncogenic mutations result in a constitutively active Gα subunit (PMID: 1328859PMID: 2549426). Receptor activation causes the dissociation of the Gα subunit from Gßγ. Both Gα and Gßγ can then activate downstream cellular signaling pathways (PMID: 1328859PMID: 2549426).

GNA11 is altered in 0.67% of all cancers with uveal melanoma, colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations [3].

GNA11 GENIE Cases - Top Diseases

The most common alterations in GNA11 are GNA11 Mutation (0.72%), GNA11 Loss (0.16%), GNA11 Q209L (0.13%), GNA11 Amplification (0.05%), and GNA11 R183C (0.02%) [3].

GNA11 GENIE Cases - Top Alterations

Significance of GNA11 in Diseases

Uveal Melanoma +

Melanoma +

Cutaneous Melanoma +

Colorectal Carcinoma +

Malignant Solid Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.