Location [1]
Protein [2]
Histone deacetylase 1
Synonyms [1]
RPD3, RPD3L1, HD1, GON-10, KDAC1

Histone deacetylase 1 (HDAC1) is a gene that encodes a protein that is a member of the histone deacetylase complex. The protein functions in histone deacetylation, cell proliferation and differentiation, and interacts with retinoblastoma tumor-suppressor protein. Missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as breast cancer, endometrial cancer, and intestinal cancer.

HDAC1 is altered in 0.32% of all cancers with diffuse large B-cell lymphoma, not otherwise specified, colon adenocarcinoma, B-cell lymphoblastic leukemia/lymphoma, rectal adenocarcinoma, and colorectal adenocarcinoma having the greatest prevalence of alterations [3].

HDAC1 GENIE Cases - Top Diseases

The most common alterations in HDAC1 are HDAC1 Mutation (0.24%), HDAC1 Loss (0.09%), HDAC1 T322M (0.19%), HDAC1 C151Y (0.08%), and HDAC1 D130N (0.08%) [3].

HDAC1 GENIE Cases - Top Alterations

Significance of HDAC1 in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Prostate Carcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Colorectal Carcinoma +

Cervical Carcinoma +

Primary Peritoneal Carcinoma +

Endometrial Carcinoma +

Non-Small Cell Lung Carcinoma +

Non-Hodgkin Lymphoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Fallopian Tube Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Malignant Intestinal Neoplasm +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Diffuse Large B-Cell Lymphoma +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

Bladder Urothelial Carcinoma +

Cholangiocarcinoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Gastrointestinal Stromal Tumor +

High Grade Ovarian Serous Adenocarcinoma +

Malignant Esophagogastric Neoplasm +

Malignant Gastric Neoplasm +

Malignant Ovarian Epithelial Tumor +

Malignant Small Intestinal Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Penile Carcinoma +

Small Cell Lung Carcinoma +

Soft Tissue Sarcoma +

Urothelial Carcinoma +

Vaginal Carcinoma +

Vulvar Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.