HIP1
Huntingtin interacting protein 1 (HIP1) is a gene that encodes a membrane-associated protein that functions in protein trafficking and clathrin-mediated endocytosis. The protein is also important in the onset of Huntington’s disease. Normally, the protein binds to the huntingtin protein in the brain; this associated does not occur in Huntington’s disease. Fusions, missense mutations, nonsense mutations, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.