Location [1]
Synonyms [1]

Immunoglobulin heavy locus (IGH) is a gene that encodes for a variable region in immunoglobulins, protein complexes that recognize foreign antigens and initiate immune responses. It is not clear whether IGH mutations have been observed in human cancers.

Biomarker-Directed Therapies

Significance of IGH in Diseases

Mantle Cell Lymphoma +

Mature B-Cell Lymphoma/Leukemia +

Multiple Myeloma +

Plasma Cell Leukemia +

Chronic Lymphocytic Leukemia +

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Acute Lymphoblastic Leukemia +

Diffuse Large B-Cell Lymphoma +

Chronic Myeloid Leukemia +

Follicular Lymphoma +

Hodgkin Lymphoma +

Non-Hodgkin Lymphoma +

Smoldering Plasma Cell Myeloma +

Small Lymphocytic Lymphoma +

B-Cell Acute Lymphoblastic Leukemia +

B-Cell Non-Hodgkin Lymphoma +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Chronic Myelomonocytic Leukemia +

Grade 3b Follicular Lymphoma +

Lymphoma +

Lymphoplasmacytic Lymphoma +

Marginal Zone Lymphoma +

Waldenstrom Macroglobulinemia +

Anaplastic Large Cell Lymphoma +

Aplastic Anemia +

Cancer +

Double-Hit Lymphoma +

Lymphoblastic Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mediastinal Large B-Cell Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm +

Myelofibrosis +

Myeloma +

Myeloproliferative Neoplasm +

Plasmacytoma +

Primary Mediastinal B-Cell Lymphoma +

Prolymphocytic Leukemia +

T-Cell Prolymphocytic Leukemia +

Therapy-Related Chronic Myelomonocytic Leukemia +

Therapy-Related Myelodysplastic Syndrome +

Transformed Non-Hodgkin Lymphoma +

Triple-Hit Lymphoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.