Overview

Location [1]
14q32.33
Synonyms [1]
IGHJ@, IGHV, IGD1, IGH.1@, IGH@, IGHD@, IGHDY1, IGHJ, IGHV@

Immunoglobulin heavy locus (IGH) is a gene that encodes for a variable region in immunoglobulins, protein complexes that recognize foreign antigens and initiate immune responses. It is not clear whether IGH mutations have been observed in human cancers.

IGH is altered in 0.62% of all cancers with diffuse large B-cell lymphoma, not otherwise specified, follicular lymphoma, mature B-cell neoplasm, breast invasive ductal carcinoma, and chronic lymphocytic leukemia/small lymphocytic lymphoma having the greatest prevalence of alterations [3].

IGH GENIE Cases - Top Diseases

The most common alterations in IGH are IGH Fusion (0.32%), IGH-BCL2 Fusion (0.29%), IGH-MYC Fusion (0.23%), IGH-CCND1 Fusion (0.15%), and IGH-FGFR3 Fusion (0.08%) [3].

IGH GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of IGH in Diseases

Mantle Cell Lymphoma +

Mature B-Cell Lymphoma/Leukemia +

Multiple Myeloma +

Plasma Cell Leukemia +

Chronic Lymphocytic Leukemia +

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Acute Lymphoblastic Leukemia +

Diffuse Large B-Cell Lymphoma +

Follicular Lymphoma +

Non-Hodgkin Lymphoma +

Chronic Myeloid Leukemia +

Hodgkin Lymphoma +

Smoldering Plasma Cell Myeloma +

Small Lymphocytic Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Lymphoma +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

B-Cell Acute Lymphoblastic Leukemia +

Chronic Myelomonocytic Leukemia +

Grade 3b Follicular Lymphoma +

Lymphoplasmacytic Lymphoma +

Marginal Zone Lymphoma +

Waldenstrom Macroglobulinemia +

Myeloma +

Cancer +

Anaplastic Large Cell Lymphoma +

Aplastic Anemia +

Double-Hit Lymphoma +

Lymphoblastic Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mediastinal Large B-Cell Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm +

Myelofibrosis +

Myeloproliferative Neoplasm +

Plasmacytoma +

Primary Mediastinal B-Cell Lymphoma +

Prolymphocytic Leukemia +

T-Cell Prolymphocytic Leukemia +

Therapy-Related Chronic Myelomonocytic Leukemia +

Therapy-Related Myelodysplastic Syndrome +

Transformed Non-Hodgkin Lymphoma +

Triple-Hit Lymphoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.