Overview

Location [1]
7p12.2
Pathway
Chromatin remodeling/DNA methylation
Synonyms [1]
IKAROS, PPP1R92, PRO0758, LYF1, IK1, LyF-1, CVID13, Hs.54452, ZNFN1A1

IKAROS family zinc finger 1 (Ikaros) (IKZF1) is a gene that encodes a transcription factor protein that functions in chromatin remodeling and the regulation of lymphocyte differentiation. Fusions, missense mutations, nonsense mutations, silent mutations, whole gene deletions, and frameshift deletions and insertions are observed in cancers such as hematopoietic and lymphoid cancers, lung cancer, and skin cancer.

Significance of IKZF1 in Diseases

Acute Lymphoblastic Leukemia +

Acute Myeloid Leukemia +

Anaplastic Large Cell Lymphoma +

Burkitt Lymphoma +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Chronic Myeloid Leukemia +

Follicular Lymphoma +

Lymphoplasmacytic Lymphoma +

Mantle Cell Lymphoma +

Marginal Zone Lymphoma +

Multiple Myeloma +

Myelodysplastic Syndromes +

B-Cell Acute Lymphoblastic Leukemia +

Hodgkin Lymphoma +

Lymphoblastic Lymphoma +

Myelofibrosis +

Myeloproliferative Neoplasm +

Plasma Cell Leukemia +

Prolymphocytic Leukemia +

Acute Biphenotypic Leukemia +

Acute Leukemia +

Acute Undifferentiated Leukemia +

B-Cell Prolymphocytic Leukemia +

Mature T-Cell And NK-Cell Neoplasm +

Myelodysplastic Syndrome With Excess Blasts-1 +

Myelodysplastic Syndrome With Excess Blasts-2 +

Non-Hodgkin Lymphoma +

T-Cell And NK-Cell Neoplasm +

Therapy-Related Myelodysplastic Syndrome +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.