Overview

Location [1]
5p13.2
Pathway
Immune checkpoints
Protein [2]
Interleukin-7 receptor subunit alpha
Synonyms [1]
CDW127, CD127, IL7RA, IL-7R-alpha, ILRA

Interleukin 7 receptor (IL7R) is a gene that encodes a protein that functions as a receptor for interleukin 7. The protein also plays an important role in V(D)J recombination during lymphocyte development. Missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame insertions are observed in cancers such as endometrial cancer, lung cancer, and skin cancer.

IL7R is altered in 1.85% of all cancers with lung adenocarcinoma, cutaneous melanoma, colon adenocarcinoma, melanoma, and squamous cell lung carcinoma having the greatest prevalence of alterations [3].

IL7R GENIE Cases - Top Diseases

The most common alterations in IL7R are IL7R Mutation (1.15%), IL7R Amplification (0.53%), IL7R I121* (0.04%), IL7R R206* (0.04%), and IL7R R267Gfs*28 (0.03%) [3].

IL7R GENIE Cases - Top Alterations

Significance of IL7R in Diseases

Acute Lymphoblastic Leukemia +

B-Cell Acute Lymphoblastic Leukemia +

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

B-Cell Lymphoblastic Leukemia/Lymphoma +

Chronic Myeloid Leukemia +

Chronic Myelomonocytic Leukemia +

Mixed Phenotype Acute Leukemia +

Secondary Acute Myeloid Leukemia +

T-Cell Lymphoblastic Leukemia/Lymphoma +

Therapy-Related Acute Myeloid Leukemia +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.