Location [1]
Chromatin remodeling/DNA methylation
Protein [2]
Histone acetyltransferase KAT6A
Synonyms [1]

K (lysine) acetyltransferase 6A (KAT6A; also known as MYST3) is a gene that encodes a protein that acetylates lysine residues in histone H3 and H4. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions and insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

KAT6A is altered in 3.09% of all cancers with colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, melanoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

KAT6A GENIE Cases - Top Diseases

The most common alterations in KAT6A are KAT6A Amplification (1.15%), KAT6A-EP300 Fusion (0.17%), KAT6A-CREBBP Fusion (0.14%), KAT6A Fusion (0.21%), and KAT6A Q1667H (1.56%) [3].

KAT6A GENIE Cases - Top Alterations

Significance of KAT6A in Diseases

Acute Lymphoblastic Leukemia +

Chronic Myeloid Leukemia +

Myelodysplastic Syndromes +

Acute Myeloid Leukemia +

Non-Hodgkin Lymphoma +

Acute Biphenotypic Leukemia +

Acute Erythroid Leukemia +

Acute Megakaryoblastic Leukemia +

Acute Undifferentiated Leukemia +

Hodgkin Lymphoma +

Juvenile Myelomonocytic Leukemia +

Myeloid Sarcoma +

Natural Killer Cell Lymphoblastic Leukemia/Lymphoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.