Overview

Location [1]
4q12
Protein [2]
Vascular endothelial growth factor receptor 2
Synonyms [1]
FLK1, CD309, VEGFR2, VEGFR

Kinase insert domain receptor (KDR) is a gene that encodes a protein that functions as a type III receptor tyrosine kinase of vascular endothelial growth factor (VEGF). The protein regulates VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis, and sprouting. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as intestinal cancer, lung cancer, and skin cancer.

KDR is altered in 2.74% of all cancers with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, melanoma, and conventional glioblastoma multiforme having the greatest prevalence of alterations [3].

KDR GENIE Cases - Top Diseases

The most common alterations in KDR are KDR Mutation (3.49%), KDR Missense (3.17%), KDR Amplification (0.49%), KDR Nonsense (0.26%), and KDR Frameshift (0.08%) [3].

KDR GENIE Cases - Top Alterations

Significance of KDR in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Pancreatic Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Melanoma +

Bladder Carcinoma +

Colorectal Carcinoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Ovarian Carcinoma +

Breast Carcinoma +

Urothelial Carcinoma +

Lung Carcinoma +

Malignant Uterine Neoplasm +

Glioblastoma +

Anaplastic Astrocytoma +

Cancer +

Esophageal Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Cervical Carcinoma +

Lymphoma +

Sarcoma +

Hepatobiliary Neoplasm +

Malignant Hepatobiliary Neoplasm +

Malignant Salivary Gland Neoplasm +

Gastrointestinal Stromal Tumor +

Bile Duct Carcinoma +

Bronchogenic Carcinoma +

Esophageal Squamous Cell Carcinoma +

Fallopian Tube Carcinoma +

Gallbladder Carcinoma +

Head And Neck Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Lip And Oral Cavity Carcinoma +

Malignant Laryngeal Neoplasm +

Multiple Myeloma +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Oropharyngeal Carcinoma +

Primary Peritoneal Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.