Location [1]
Protein [2]
Kinesin-1 heavy chain
Synonyms [1]

Kinesin family member 5B (KIF5B) is a gene that encodes a protein that functions as a microtubule-dependent motor that regulates the normal distribution of mitochondria and lysosomes. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

KIF5B is altered in 0.27% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, non-small cell lung carcinoma, poorly differentiated non-small cell lung cancer, and diffuse large B-cell lymphoma, not otherwise specified having the greatest prevalence of alterations [3].

KIF5B GENIE Cases - Top Diseases

The most common alterations in KIF5B are KIF5B-RET Fusion (0.17%), KIF5B-MET Fusion (0.08%), KIF5B-ALK Fusion (0.04%), KIF5B E170V (0.30%), and KIF5B R278Q (0.30%) [3].

KIF5B GENIE Cases - Top Alterations

Significance of KIF5B in Diseases

Thyroid Gland Papillary Carcinoma +

Malignant Solid Tumor +

Lymphoma +

Histiocytosis +

Poorly Differentiated Thyroid Gland Carcinoma +

Thyroid Gland Medullary Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.