Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
16q23.2
Protein [2]
Transcription factor Maf
Synonyms [1]
CCA4, AYGRP, c-MAF, CTRCT21

V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog (MAF) is a gene that encodes a protein that, depending on the binding site and binding partner, functions as a transcriptional activator or repressor. The protein is also involved in the regulation of cellular processes such as embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Fusions, missense mutations, nonsense mutations, silent mutations, and in-frame deletions are observed in cancers such as intestinal cancer, stomach cancer, and urinary tract cancer.

MAF is altered in 0.07% of all cancers.

The most common alterations in MAF are MAF Loss (0.01%) and MAF Amplification (0.00%) [3].

MAF GENIE Cases - Top Alterations

Significance of MAF in Diseases

Multiple Myeloma +

Plasma Cell Leukemia +

Chronic Lymphocytic Leukemia +

Acute Myeloid Leukemia +

Chronic Myeloid Leukemia +

Myelodysplastic Syndromes +

Non-Hodgkin Lymphoma +

Acute Lymphoblastic Leukemia +

Chronic Myelomonocytic Leukemia +

Hodgkin Lymphoma +

Lymphoma +

Aplastic Anemia +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Diffuse Large B-Cell Lymphoma +

Double-Hit Lymphoma +

Lymphoblastic Lymphoma +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Myelodysplastic/Myeloproliferative Neoplasm +

Myelofibrosis +

Myeloproliferative Neoplasm +

Plasmacytoma +

Prolymphocytic Leukemia +

Small Lymphocytic Lymphoma +

T-Cell Prolymphocytic Leukemia +

Therapy-Related Chronic Myelomonocytic Leukemia +

Therapy-Related Myelodysplastic Syndrome +

Triple-Hit Lymphoma +

Waldenstrom Macroglobulinemia +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.