Overview

Location [1]
17q24.3
Protein [2]
Dual specificity mitogen-activated protein kinase kinase 6
Synonyms [1]
MAPKK6, MEK6, SAPKK3, SAPKK-3, MKK6, PRKMK6

MAP2K6 is altered in 0.01% of all cancers with glioblastoma, small cell lung carcinoma, and unknown having the greatest prevalence of alterations [3].

MAP2K6 GENIE Cases - Top Diseases

The most common alterations in MAP2K6 are MAP2K6-BRCA1 Fusion (0.00%), MAP2K6-BRIP1 Fusion (0.00%), and MAP2K6-EPHA7 Fusion (0.03%) [3].

MAP2K6 GENIE Cases - Top Alterations

Significance of MAP2K6 in Diseases

Cholangiocarcinoma +

Colorectal Carcinoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Pancreatic Adenocarcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.