Overview

Location [1]
16p11.2
Protein [2]
Mitogen-activated protein kinase 3
Synonyms [1]
ERK-1, PRKM3, P44ERK1, ERK1, HS44KDAP, ERT2, P44MAPK, p44-ERK1, p44-MAPK, HUMKER1A

MAPK3 is altered in 0.29% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, colon adenocarcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

MAPK3 GENIE Cases - Top Diseases

The most common alterations in MAPK3 are MAPK3 Amplification (0.12%) and MAPK3 Loss (0.03%) [3].

MAPK3 GENIE Cases - Top Alterations

Significance of MAPK3 in Diseases

Colorectal Carcinoma +

Malignant Solid Tumor +

Cholangiocarcinoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Pancreatic Adenocarcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.