Biomarkers /
MSH3
Overview
MutS homolog 3 (MSH3) is a gene that encodes a protein that is a component of MutS beta - a post-replicative DNA mismatch repair system. The protein functions in DNA mismatch repair. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.
MSH3 is altered in 2.28% of all cancers with colon adenocarcinoma, endometrial endometrioid adenocarcinoma, lung adenocarcinoma, prostate adenocarcinoma, and conventional glioblastoma multiforme having the greatest prevalence of alterations [3].
The most common alterations in MSH3 are MSH3 Mutation (1.32%), MSH3 A60_A62dup (2.37%), MSH3 Loss (0.11%), MSH3 A61_P63dup (0.32%), and MSH3 Amplification (0.02%) [3].
Clinical Trials
Significance of MSH3 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.