Overview

Location [1]
1p34.1
Pathway
DNA damage/repair
Protein [2]
Adenine DNA glycosylase
Synonyms [1]
MYH

The mutY homolog (MUTYH) gene encodes a protein that functions in oxidative DNA damage repair. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

MUTYH is altered in 0.87% of all cancers with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, endometrial endometrioid adenocarcinoma, and conventional glioblastoma multiforme having the greatest prevalence of alterations [3].

MUTYH GENIE Cases - Top Diseases

The most common alterations in MUTYH are MUTYH Mutation (0.92%), MUTYH Amplification (0.07%), MUTYH A416T (0.02%), MUTYH Deletion (0.02%), and MUTYH Loss (0.02%) [3].

MUTYH GENIE Cases - Top Alterations

Significance of MUTYH in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Prostate Carcinoma +

Ovarian Carcinoma +

Breast Carcinoma +

Primary Peritoneal Carcinoma +

Urothelial Carcinoma +

Non-Hodgkin Lymphoma +

Cervical Carcinoma +

Fallopian Tube Carcinoma +

Endometrial Carcinoma +

Colorectal Carcinoma +

Non-Small Cell Lung Carcinoma +

Cholangiocarcinoma +

Head And Neck Squamous Cell Carcinoma +

Esophageal Carcinoma +

Bladder Urothelial Carcinoma +

Bladder Carcinoma +

Malignant Intestinal Neoplasm +

Malignant Esophagogastric Neoplasm +

Soft Tissue Sarcoma +

Malignant Ovarian Epithelial Tumor +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

Clear Cell Renal Cell Carcinoma +

Diffuse Large B-Cell Lymphoma +

Gastric Carcinoma +

Gastrointestinal Stromal Tumor +

Hepatocellular Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Kidney Carcinoma +

Malignant Gastric Neoplasm +

Malignant Small Intestinal Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Penile Carcinoma +

Small Cell Lung Carcinoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.