Overview

Location [1]
1p34.1
Pathway
DNA damage/repair
Protein [2]
Adenine DNA glycosylase
Synonyms [1]
MYH

The mutY homolog (MUTYH) gene encodes a protein that functions in oxidative DNA damage repair. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

MUTYH is altered in 1.03% of all cancers with non-small cell lung carcinoma, colorectal adenocarcinoma, breast carcinoma, uterine corpus neoplasm, and melanoma having the greatest prevalence of alterations [3].

MUTYH GENIE Cases - Top Diseases

The most common alterations in MUTYH are MUTYH Mutation (0.92%), MUTYH Amplification (0.07%), MUTYH A416T (0.02%), MUTYH Deletion (0.02%), and MUTYH Loss (0.02%) [3].

MUTYH GENIE Cases - Top Alterations

Significance of MUTYH in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Breast Carcinoma +

Prostate Carcinoma +

Ovarian Carcinoma +

Non-Hodgkin Lymphoma +

Urothelial Carcinoma +

Colorectal Carcinoma +

Cervical Carcinoma +

Small Cell Lung Carcinoma +

Cholangiocarcinoma +

Gastric Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Endometrial Carcinoma +

Bladder Carcinoma +

Soft Tissue Sarcoma +

Lung Adenocarcinoma +

Non-Small Cell Lung Carcinoma +

Diffuse Large B-Cell Lymphoma +

Head And Neck Squamous Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Clear Cell Renal Cell Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Anal Carcinoma +

Fallopian Tube Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Penile Carcinoma +

Peritoneal Carcinoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.