Biomarkers /
NCOA4
Overview
NCOA4 is altered in 0.09% of all cancers with thyroid gland papillary carcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, and adenocarcinoma of unknown primary having the greatest prevalence of alterations [3].
The most common alterations in NCOA4 are NCOA4-RET Fusion (0.06%), NCOA4 A227V (0.39%), NCOA4 C426Y (0.85%), NCOA4 E436D (0.39%), and NCOA4 E485Q (0.20%) [3].
Clinical Trials
Significance of NCOA4 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.