Biomarkers /
NFE2L2
Overview
Nuclear factor, erythroid 2-like 2 (NFE2L2) is a gene that encodes a transcription factor protein that is a member of a family of leucine zipper proteins. The protein functions in the regulation of antioxidant response elements that promote immunological responses such as inflammation. Missense mutations, nonsense mutations, silent mutations, and in-frame insertions and deletions are observed in cancers such as esophageal cancer, liver cancer, and lung cancer.
Clinical Trials
Significance of NFE2L2 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.