Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
Nuclear factor NF-kappa-B p52 subunit
Synonyms [1]
LYT-10, H2TF1, p100, NF-kB2, CVID10, p49/p100, p52, LYT10

Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) (NFKB2) is a gene that encodes a protein that functions as a subunit of the transcription factor complex nuclear factor-kappa-B. The protein activates genes that participate in inflammation and immunity. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as bone cancer, endometrial cancer, and skin cancer.

NFKB2 is altered in 1.32% of all cancers with cervical squamous cell carcinoma, endometrial endometrioid adenocarcinoma, high grade ovarian serous adenocarcinoma, ovarian epithelial tumor, and anaplastic astrocytoma having the greatest prevalence of alterations [3].

NFKB2 GENIE Cases - Top Diseases

The most common alterations in NFKB2 are NFKB2 Mutation (1.25%), NFKB2 P430S (0.36%), NFKB2 A572T (0.28%), NFKB2 A420T (0.22%), and NFKB2 A675T (0.39%) [3].

NFKB2 GENIE Cases - Top Alterations

Significance of NFKB2 in Diseases

Multiple Myeloma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.