Biomarkers /
NUP98
Overview
Nucleoporin 98kDa (NUP98) is a gene that encodes a nucleoporin protein that functions in nuclear transport - the export and import through the nuclear pore complex (NPC). The protein's specific function may be that of a nucleoporin docking protein. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.
NUP98 is altered in 0.73% of all cancers with colon adenocarcinoma, breast invasive ductal carcinoma, lung adenocarcinoma, high grade ovarian serous adenocarcinoma, and pancreatic adenocarcinoma having the greatest prevalence of alterations [3].
The most common alterations in NUP98 are NUP98-FGFR1 Fusion (0.22%), NUP98-NSD1 Fusion (0.09%), NUP98-KDM5A Fusion (0.06%), NUP98-WHSC1L1 Fusion (0.06%), and NUP98 A237T (0.64%) [3].
Clinical Trials
Significance of NUP98 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.