Biomarkers /
PARP1
Overview
Poly (ADP-ribose) polymerase 1 (PARP1) is a gene that encodes a protein that is involved in the regulation of cellular processes such as differentiation, proliferation, tumor transformation, and recovery from DNA damage. Missense mutations, silent mutations, nonsense mutations, and frameshift deletions are observed in cancers such as testicular cancer, parathyroid cancer, and stomach cancer.
PARP1 is altered in 1.36% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].
The most common alterations in PARP1 are PARP1 Mutation (0.90%), PARP1 Amplification (0.32%), PARP1 Loss (0.08%), PARP1 R138C (0.02%), and PARP1 E296K (0.02%) [3].
Clinical Trials
Significance of PARP1 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.