Overview

Location [1]
1q42.12
Protein [2]
Poly [ADP-ribose] polymerase 1
Synonyms [1]
ADPRT1, PARP, ADPRT, PARP-1, ARTD1, pADPRT-1, "ADPRT 1", PPOL

Poly (ADP-ribose) polymerase 1 (PARP1) is a gene that encodes a protein that is involved in the regulation of cellular processes such as differentiation, proliferation, tumor transformation, and recovery from DNA damage. Missense mutations, silent mutations, nonsense mutations, and frameshift deletions are observed in cancers such as testicular cancer, parathyroid cancer, and stomach cancer.

PARP1 is altered in 1.06% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, cutaneous melanoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

PARP1 GENIE Cases - Top Diseases

The most common alterations in PARP1 are PARP1 Mutation (0.55%), PARP1 Amplification (0.17%), PARP1 Loss (0.03%), PARP1 S507Afs*17 (0.01%), and PARP1 A237Pfs*2 (0.01%) [3].

PARP1 GENIE Cases - Top Alterations

Significance of PARP1 in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Prostate Carcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Primary Peritoneal Carcinoma +

Cervical Carcinoma +

Fallopian Tube Carcinoma +

Non-Hodgkin Lymphoma +

Endometrial Carcinoma +

Urothelial Carcinoma +

Colorectal Carcinoma +

Non-Small Cell Lung Carcinoma +

Cholangiocarcinoma +

Head And Neck Squamous Cell Carcinoma +

Bladder Urothelial Carcinoma +

Melanoma +

Malignant Intestinal Neoplasm +

Malignant Esophagogastric Neoplasm +

Adenocarcinoma Of The Gastroesophageal Junction +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

Clear Cell Renal Cell Carcinoma +

Diffuse Large B-Cell Lymphoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Gastrointestinal Stromal Tumor +

Hepatocellular Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Kidney Carcinoma +

Malignant Gastric Neoplasm +

Malignant Ovarian Epithelial Tumor +

Malignant Small Intestinal Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Penile Carcinoma +

Small Cell Lung Carcinoma +

Soft Tissue Sarcoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.