Overview

Location [1]
1q42.12
Protein [2]
Poly [ADP-ribose] polymerase 1
Synonyms [1]
ADPRT1, pADPRT-1, ADPRT, "ADPRT 1", PARP, PARP-1, PPOL, ARTD1

Poly (ADP-ribose) polymerase 1 (PARP1) is a gene that encodes a protein that is involved in the regulation of cellular processes such as differentiation, proliferation, tumor transformation, and recovery from DNA damage. Missense mutations, silent mutations, nonsense mutations, and frameshift deletions are observed in cancers such as testicular cancer, parathyroid cancer, and stomach cancer.

PARP1 is altered in 1.27% of all cancers with breast carcinoma, non-small cell lung carcinoma, colorectal adenocarcinoma, uterine corpus neoplasm, and melanoma having the greatest prevalence of alterations [3].

PARP1 GENIE Cases - Top Diseases

The most common alterations in PARP1 are PARP1 Mutation (0.55%), PARP1 Amplification (0.17%), PARP1 Loss (0.03%), PARP1 S507Afs*17 (0.01%), and PARP1 A237Pfs*2 (0.01%) [3].

PARP1 GENIE Cases - Top Alterations

Significance of PARP1 in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Breast Carcinoma +

Prostate Carcinoma +

Ovarian Carcinoma +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Cervical Carcinoma +

Small Cell Lung Carcinoma +

Cholangiocarcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Gastric Carcinoma +

Endometrial Carcinoma +

Anal Carcinoma +

Urothelial Carcinoma +

Lung Adenocarcinoma +

Non-Small Cell Lung Carcinoma +

Mesothelioma +

High Grade Ovarian Serous Adenocarcinoma +

Clear Cell Renal Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Soft Tissue Sarcoma +

Head And Neck Squamous Cell Carcinoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Diffuse Large B-Cell Lymphoma +

Fallopian Tube Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Penile Carcinoma +

Peritoneal Carcinoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.