Overview

Location [1]
14q11.2
Protein [2]
Poly [ADP-ribose] polymerase 2
Synonyms [1]
ADPRTL2, ADPRTL3, ADPRT2, pADPRT-2, ARTD2, PARP-2

PARP2 is altered in 0.89% of all cancers with colon adenocarcinoma, invasive breast carcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

PARP2 GENIE Cases - Top Diseases

The most common alterations in PARP2 are PARP2 Mutation (0.89%), PARP2 D95A (0.30%), PARP2 G442V (0.30%), and PARP2 R41T (0.30%) [3].

PARP2 GENIE Cases - Top Alterations

Significance of PARP2 in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Prostate Carcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Colorectal Carcinoma +

Cervical Carcinoma +

Non-Hodgkin Lymphoma +

Primary Peritoneal Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Cholangiocarcinoma +

Endometrial Carcinoma +

Fallopian Tube Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Non-Small Cell Lung Carcinoma +

Malignant Intestinal Neoplasm +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

Bladder Urothelial Carcinoma +

Clear Cell Renal Cell Carcinoma +

Diffuse Large B-Cell Lymphoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Gastrointestinal Stromal Tumor +

High Grade Ovarian Serous Adenocarcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Malignant Esophagogastric Neoplasm +

Malignant Gastric Neoplasm +

Malignant Ovarian Epithelial Tumor +

Malignant Small Intestinal Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Penile Carcinoma +

Small Cell Lung Carcinoma +

Soft Tissue Sarcoma +

Urothelial Carcinoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.