Overview

Location [1]
Xq26.2
Synonyms [1]
BFLS, CENP-31, BORJ

PHD finger protein 6 (PHF6) is a gene that encodes a protein with two PHD-type zinc finger domains. Missense mutations, nonsense mutations, frameshift insertions and deletions, and whole gene deletions are observed in cancers such as acute lymphoblastic leukemia, lung cancer, and skin cancer.

Significance of PHF6 in Diseases

Acute Myeloid Leukemia +

Acute Lymphoblastic Leukemia +

Aplastic Anemia +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Chronic Myeloid Leukemia +

Chronic Myelomonocytic Leukemia +

Hodgkin Lymphoma +

Lymphoblastic Lymphoma +

Multiple Myeloma +

Myelodysplastic Syndrome With Excess Blasts-2 +

Myelodysplastic Syndromes +

Myeloid Neoplasm +

Non-Hodgkin Lymphoma +

Therapy-Related Chronic Myelomonocytic Leukemia +

Therapy-Related Myelodysplastic Syndrome +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.