Overview

Location [1]
19q13.41
Pathway
DNA damage/repair
Protein [2]
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Synonyms [1]
PP2AAALPHA, MRD36, PR65A, PP2AA, PP2A-Aalpha

Protein phosphatase 2, regulatory subunit A, alpha (PPP2R1A) is a gene that encodes a protein that is a subunit of protein phosphatase 2, a complex implicated in the negative control of cell growth and division. Missense mutations, silent mutations, frameshift deletions, and nonsense mutations are observed in cancers such as endometrial cancer, colon cancer, and vulvar cancer.

PPP2R1A is altered in 1.53% of all cancers with endometrial serous adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, lung adenocarcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

PPP2R1A GENIE Cases - Top Diseases

The most common alterations in PPP2R1A are PPP2R1A Mutation (1.20%), PPP2R1A Amplification (0.16%), PPP2R1A R183W (0.15%), PPP2R1A P179R (0.14%), and PPP2R1A S256F (0.10%) [3].

PPP2R1A GENIE Cases - Top Alterations

Significance of PPP2R1A in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Prostate Carcinoma +

Ovarian Carcinoma +

Breast Carcinoma +

Primary Peritoneal Carcinoma +

Cervical Carcinoma +

Fallopian Tube Carcinoma +

Non-Hodgkin Lymphoma +

Endometrial Carcinoma +

Colorectal Carcinoma +

Urothelial Carcinoma +

Cholangiocarcinoma +

Non-Small Cell Lung Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Malignant Small Intestinal Neoplasm +

Malignant Ovarian Epithelial Tumor +

Malignant Intestinal Neoplasm +

High Grade Ovarian Serous Adenocarcinoma +

Gastric Carcinoma +

Malignant Gastric Neoplasm +

Bladder Urothelial Carcinoma +

Malignant Esophagogastric Neoplasm +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

Clear Cell Renal Cell Carcinoma +

Diffuse Large B-Cell Lymphoma +

Esophageal Carcinoma +

Gastrointestinal Stromal Tumor +

Hepatocellular Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Kidney Carcinoma +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Penile Carcinoma +

Small Cell Lung Carcinoma +

Soft Tissue Sarcoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.