Overview

Location [1]
19q13.41
Pathway
DNA damage/repair
Protein [2]
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Synonyms [1]
PR65A, PP2AAALPHA, PP2AA, PP2A-Aalpha, MRD36

Protein phosphatase 2, regulatory subunit A, alpha (PPP2R1A) is a gene that encodes a protein that is a subunit of protein phosphatase 2, a complex implicated in the negative control of cell growth and division. Missense mutations, silent mutations, frameshift deletions, and nonsense mutations are observed in cancers such as endometrial cancer, colon cancer, and vulvar cancer.

PPP2R1A is altered in 1.87% of all cancers with uterine corpus neoplasm, colorectal adenocarcinoma, breast carcinoma, non-small cell lung carcinoma, and ovarian neoplasm having the greatest prevalence of alterations [3].

PPP2R1A GENIE Cases - Top Diseases

The most common alterations in PPP2R1A are PPP2R1A Mutation (1.20%), PPP2R1A Amplification (0.16%), PPP2R1A R183W (0.15%), PPP2R1A P179R (0.14%), and PPP2R1A S256F (0.10%) [3].

PPP2R1A GENIE Cases - Top Alterations

Significance of PPP2R1A in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Breast Carcinoma +

Prostate Carcinoma +

Ovarian Carcinoma +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Gastric Carcinoma +

Cervical Carcinoma +

Cholangiocarcinoma +

Small Cell Lung Carcinoma +

Endometrial Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Squamous Cell Lung Carcinoma +

Urothelial Carcinoma +

Non-Small Cell Lung Carcinoma +

Anal Carcinoma +

Lung Adenocarcinoma +

Head And Neck Squamous Cell Carcinoma +

Soft Tissue Sarcoma +

Diffuse Large B-Cell Lymphoma +

Mesothelioma +

Clear Cell Renal Cell Carcinoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Fallopian Tube Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Penile Carcinoma +

Peritoneal Carcinoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.