Location [1]
DNA damage/repair
Protein [2]
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Synonyms [1]

Protein phosphatase 2, regulatory subunit A, alpha (PPP2R1A) is a gene that encodes a protein that is a subunit of protein phosphatase 2, a complex implicated in the negative control of cell growth and division. Missense mutations, silent mutations, frameshift deletions, and nonsense mutations are observed in cancers such as endometrial cancer, colon cancer, and vulvar cancer.

PPP2R1A is altered in 1.82% of all cancers with endometrial serous adenocarcinoma, endometrial endometrioid adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, and lung adenocarcinoma having the greatest prevalence of alterations [3].

PPP2R1A GENIE Cases - Top Diseases

The most common alterations in PPP2R1A are PPP2R1A Mutation (1.49%), PPP2R1A Amplification (0.26%), PPP2R1A P179R (0.22%), PPP2R1A R183W (0.20%), and PPP2R1A S256F (0.16%) [3].

PPP2R1A GENIE Cases - Top Alterations

Significance of PPP2R1A in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Prostate Carcinoma +

Ovarian Carcinoma +

Breast Carcinoma +

Colorectal Carcinoma +

Cervical Carcinoma +

Primary Peritoneal Carcinoma +

Endometrial Carcinoma +

Fallopian Tube Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Non-Small Cell Lung Carcinoma +

Non-Hodgkin Lymphoma +

Head And Neck Squamous Cell Carcinoma +

Malignant Small Intestinal Neoplasm +

Malignant Ovarian Epithelial Tumor +

Ampulla Of Vater Carcinoma +

Malignant Intestinal Neoplasm +

Bladder Urothelial Carcinoma +

Diffuse Large B-Cell Lymphoma +

High Grade Ovarian Serous Adenocarcinoma +

Gastric Carcinoma +

Malignant Gastric Neoplasm +

Urothelial Carcinoma +

Malignant Esophagogastric Neoplasm +

Mantle Cell Lymphoma +

Cholangiocarcinoma +

Esophageal Carcinoma +

Anal Carcinoma +

Soft Tissue Sarcoma +

Gastrointestinal Stromal Tumor +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Small Cell Lung Carcinoma +

Penile Carcinoma +

Vaginal Carcinoma +

Vulvar Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.