Overview

Location [1]
8p21.2
Protein [2]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Synonyms [1]
PR52A, B55A, B55ALPHA, PR55alpha, PR55A

PPP2R2A is altered in 1.69% of all cancers with breast carcinoma having the greatest prevalence of alterations [3].

PPP2R2A GENIE Cases - Top Diseases

The most common alterations in PPP2R2A are PPP2R2A Loss (0.03%), PPP2R2A Mutation (0.03%), PPP2R2A Amplification (0.03%), PPP2R2A N386S (0.00%), and PPP2R2A D406E (0.00%) [3].

PPP2R2A GENIE Cases - Top Alterations

Significance of PPP2R2A in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Ovarian Carcinoma +

Breast Carcinoma +

Prostate Carcinoma +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Cervical Carcinoma +

Cholangiocarcinoma +

Fallopian Tube Carcinoma +

Gastric Carcinoma +

Small Cell Lung Carcinoma +

Anal Carcinoma +

Clear Cell Renal Cell Carcinoma +

Diffuse Large B-Cell Lymphoma +

Endometrial Carcinoma +

Head And Neck Squamous Cell Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Lung Adenocarcinoma +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Non-Small Cell Lung Carcinoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Penile Carcinoma +

Peritoneal Carcinoma +

Primary Peritoneal Carcinoma +

Renal Cell Carcinoma +

Soft Tissue Sarcoma +

Squamous Cell Lung Carcinoma +

Urothelial Carcinoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.