Location [1]
Protein [2]
GTP-binding protein Rheb
Synonyms [1]

Ras homolog enriched in brain (RHEB) is a gene that encodes a lipid-anchored, cell membrane protein. The protein regulates cell growth and cell cycle progression. Missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

RHEB is altered in 0.38% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, breast invasive ductal carcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

RHEB GENIE Cases - Top Diseases

The most common alterations in RHEB are RHEB Mutation (0.21%), RHEB Amplification (0.12%), RHEB Loss (0.05%), RHEB S16F (0.02%), and RHEB Y35C (0.01%) [3].

RHEB GENIE Cases - Top Alterations

Significance of RHEB in Diseases

B-Cell Non-Hodgkin Lymphoma +

Cancer +

Malignant Solid Tumor +

Multiple Myeloma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.