Associated Genetic Biomarkers
Ras homolog enriched in brain (RHEB) is a gene that encodes a lipid-anchored, cell membrane protein. The protein regulates cell growth and cell cycle progression. Missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.
RHEB is altered in 0.38% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, breast invasive ductal carcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations .
The most common alterations in RHEB are RHEB Mutation (0.21%), RHEB Amplification (0.12%), RHEB Loss (0.05%), RHEB S16F (0.02%), and RHEB Y35C (0.01%) .
RHEB status serves as an inclusion eligibility criteria in 2 clinical trials, of which 1 is open and 1 is closed. Of the trials that contain RHEB status as an inclusion criterion, 1 is early phase 1 (0 open) and 1 is phase 2 (1 open).
Trials with RHEB status in the inclusion eligibility criteria most commonly target B-cell non-hodgkin lymphoma, malignant solid tumor, and multiple myeloma .
The most frequent alteration to serve as an inclusion eligibility criterion is RHEB Mutation .
Temsirolimus is the most frequent therapy in trials with RHEB as an inclusion criteria .
Significance of RHEB in Diseases
B-Cell Non-Hodgkin Lymphoma +
RHEB is altered in 0.5% of B-cell non-hodgkin lymphoma patients .
RHEB is an inclusion criterion in 1 clinical trial for B-cell non-hodgkin lymphoma, of which 1 is open and 0 are closed. Of the trial that contains RHEB status and B-cell non-hodgkin lymphoma as inclusion criteria, 1 is phase 2 (1 open) .
Malignant Solid Tumor +
Multiple Myeloma +
RHEB is an inclusion criterion in 1 clinical trial for multiple myeloma, of which 1 is open and 0 are closed. Of the trial that contains RHEB status and multiple myeloma as inclusion criteria, 1 is phase 2 (1 open) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.