Overview

Location [1]
17q22
Pathway
PI3K/AKT1/MTOR
Synonyms [1]
SSPCS, URCC, RNF124

Ring finger protein 43 (RNF43) is a gene that encodes a protein that functions as a ubiquitin ligase that facilitate cell growth. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as biliary tract cancers, intestinal cancer, and stomach cancer.

Significance of RNF43 in Diseases

Colorectal Carcinoma +

Malignant Solid Tumor +

Breast Carcinoma +

Cervical Squamous Cell Carcinoma +

Esophageal Squamous Cell Carcinoma +

Head And Neck Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Melanoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Squamous Cell Lung Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.