Overview

Location [1]
17q21.2
Pathway
JAK/STAT signaling
Protein [2]
Signal transducer and activator of transcription 3
Synonyms [1]
HIES, ADMIO, ADMIO1, APRF

Signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3) is a gene that encodes a protein that functions in transcriptional activation. Missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions and insertions are observed in cancers such as endometrial cancer, hematopoietic and lymphoid cancers, and stomach cancer.

STAT3 is altered in 1.07% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

STAT3 GENIE Cases - Top Diseases

The most common alterations in STAT3 are STAT3 Mutation (1.01%), STAT3 Amplification (0.09%), STAT3 Loss (0.04%), STAT3 E616del (0.03%), and STAT3 E616G (0.01%) [3].

STAT3 GENIE Cases - Top Alterations

Significance of STAT3 in Diseases

Non-Small Cell Lung Carcinoma +

Malignant Solid Tumor +

Acute Myeloid Leukemia +

Hepatocellular Carcinoma +

Myelodysplastic Syndrome With Excess Blasts-2 +

Myeloid Neoplasm +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.