Overview

Location [1]
17q21.2
Pathway
JAK/STAT signaling
Protein [2]
Signal transducer and activator of transcription 5B
Synonyms [1]
STAT5

Signal transducer and activator of transcription 5B (STAT5B) is a gene that encodes a protein that functions as a transcription activator. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

STAT5B is altered in 0.85% of all cancers with colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, prostate adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

STAT5B GENIE Cases - Top Diseases

The most common alterations in STAT5B are STAT5B Mutation (0.38%), STAT5B Amplification (0.06%), STAT5B Loss (0.04%), STAT5B Q368Pfs*9 (0.04%), and STAT5B K583Nfs*16 (0.03%) [3].

STAT5B GENIE Cases - Top Alterations

Significance of STAT5B in Diseases

Malignant Solid Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.