Overview

Location [1]
9q22.2
Protein [2]
Tyrosine-protein kinase SYK
Synonyms [1]
p72-Syk

Spleen tyrosine kinase (SYK) is a gene that encodes a non-receptor type tyrosine protein kinase. The protein functions in coupling activated immunoreceptors to downstream signaling events to elicit a variety of cellular responses. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

SYK is altered in 0.92% of all cancers with cutaneous melanoma, colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

SYK GENIE Cases - Top Diseases

The most common alterations in SYK are SYK Loss (0.06%), SYK Amplification (0.05%), SYK D603N (0.02%), SYK G33fs (0.02%), and SYK A52T (0.02%) [3].

SYK GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.