Overview

Location [1]
4q24
Pathway
Chromatin remodeling/DNA methylation
Protein [2]
Methylcytosine dioxygenase TET2
Synonyms [1]
KIAA1546, MDS

Tet methylcytosine dioxygenase 2 (TET2; also known as ten-eleven translocation 2) is a gene that codes for methylcytosine dioxygenase TET2, a protein involved in epigenetic regulation of myelopoeisis (Gene 2014PMID: 24220273). TET2 is a tumor suppressor, and so in cancer, loss of TET2 function, which can occur via TET2 mutation, TET2 deletion, or IDH1 or IDH2 mutation, can cause myeloid or lymphoid transformations (PMID: 24220273). Mutations in TET2 have been found in MDS, AML, ALL, and other hematologic malignancies.

TET2 is altered in 3.71% of all cancers with acute myeloid leukemia, lung adenocarcinoma, colon adenocarcinoma, myelodysplastic syndromes, and cutaneous melanoma having the greatest prevalence of alterations [3].

TET2 GENIE Cases - Top Diseases

The most common alterations in TET2 are TET2 Mutation (4.45%), TET2 c.3310-c.4434 Missense (0.98%), TET2 c.3400-c.4331 Missense (0.90%), TET2 Nonsense (0.83%), and TET2 Frameshift (0.81%) [3].

TET2 GENIE Cases - Top Alterations

Significance of TET2 in Diseases

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Chronic Myelomonocytic Leukemia +

Lymphoma +

Acute Lymphoblastic Leukemia +

Malignant Solid Tumor +

Chronic Myeloid Leukemia +

Myelodysplastic/Myeloproliferative Neoplasm +

Non-Hodgkin Lymphoma +

Melanoma +

Bladder Carcinoma +

Anaplastic Astrocytoma +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Malignant Central Nervous System Neoplasm +

Glioblastoma +

Ovarian Carcinoma +

Breast Carcinoma +

Pancreatic Carcinoma +

Sarcoma +

Acute Biphenotypic Leukemia +

Acute Leukemia Of Ambiguous Lineage +

Aplastic Anemia +

Atypical Teratoid/Rhabdoid Tumor +

Extrarenal Rhabdoid Tumor +

Head And Neck Carcinoma +

Hepatoblastoma +

Hodgkin Lymphoma +

Lymphoblastic Lymphoma +

Mixed Phenotype Acute Leukemia +

Multiple Myeloma +

Retinoblastoma +

Rhabdoid Tumor +

Rhabdoid Tumor Of The Kidney +

Therapy-Related Chronic Myelomonocytic Leukemia +

Therapy-Related Myelodysplastic Syndrome +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.