Location [1]
Protein [2]
Protein TFG
Synonyms [1]

TRK-fused gene (TFG) is a gene that encodes a protein that is involved in the normal functioning of the endoplasmic reticulum. Fusions, missense mutations, nonsense mutations, and in-frame deletions are observed in cancers such as intestinal cancer, lung cancer, and stomach cancer.

TFG is altered in 0.19% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, dedifferentiated liposarcoma, and inflammatory myofibroblastic tumor having the greatest prevalence of alterations [3].

TFG GENIE Cases - Top Diseases

The most common alterations in TFG are TFG-MET Fusion (0.08%), TFG-ROS1 Fusion (0.05%), TFG-ALK Fusion (0.07%), TFG-NTRK1 Fusion (0.02%), and TFG-NTRK3 Fusion (0.03%) [3].

TFG GENIE Cases - Top Alterations

Significance of TFG in Diseases

Histiocytosis +

Lymphoma +

Malignant Solid Tumor +

Poorly Differentiated Thyroid Gland Carcinoma +

Thyroid Gland Medullary Carcinoma +

Thyroid Gland Papillary Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.