Overview

Location [1]
3q12.2
Synonyms [1]
HMSNP, TF6, TRKT3, SPG57

TRK-fused gene (TFG) is a gene that encodes a protein that is involved in the normal functioning of the endoplasmic reticulum. Fusions, missense mutations, nonsense mutations, and in-frame deletions are observed in cancers such as intestinal cancer, lung cancer, and stomach cancer.

Significance of TFG in Diseases

Histiocytosis +

Lymphoma +

Malignant Solid Tumor +

Poorly Differentiated Thyroid Gland Carcinoma +

Thyroid Gland Medullary Carcinoma +

Thyroid Gland Papillary Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.