Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
Non-receptor tyrosine-protein kinase TYK2
Synonyms [1]

Tyrosine kinase 2 (TYK2) is a gene that encodes a protein that propagates cytokines signals via the phosphorylation of cytokine receptor subunits. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions are observed in cancers such as eye cancer, intestinal cancer, and skin cancer.

TYK2 is altered in 0.07% of all cancers.

Significance of TYK2 in Diseases

Chronic Lymphocytic Leukemia +

Lymphoplasmacytic Lymphoma +

Lymphoproliferative Disorder +

Mantle Cell Lymphoma +

Peripheral T-Cell Lymphoma +

Primary Cutaneous T Cell Non-Hodgkin Lymphoma +

Splenic Marginal Zone Lymphoma +

Waldenstrom Macroglobulinemia +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.