Location [1]
Protein [2]
Non-receptor tyrosine-protein kinase TYK2
Synonyms [1]

Tyrosine kinase 2 (TYK2) is a gene that encodes a protein that propagates cytokines signals via the phosphorylation of cytokine receptor subunits. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions are observed in cancers such as eye cancer, intestinal cancer, and skin cancer.

TYK2 is altered in 0.30% of all cancers with colon adenocarcinoma, endometrial endometrioid adenocarcinoma, melanoma, breast invasive ductal carcinoma, and skin squamous cell carcinoma having the greatest prevalence of alterations [3].

TYK2 GENIE Cases - Top Diseases

The most common alterations in TYK2 are TYK2 Mutation (1.20%), TYK2 Amplification (0.16%), TYK2 Fusion (0.02%), TYK2 Loss (0.12%), and TYK2 P814L (0.42%) [3].

TYK2 GENIE Cases - Top Alterations

Significance of TYK2 in Diseases

Acute Lymphoblastic Leukemia +

B-Cell Acute Lymphoblastic Leukemia +

Acute Myeloid Leukemia +

Myelodysplastic Syndromes +

Mixed Phenotype Acute Leukemia +

Mantle Cell Lymphoma +

Chronic Myelomonocytic Leukemia +

Lymphoproliferative Disorder +

B-Cell Lymphoblastic Lymphoma +

Chronic Lymphocytic Leukemia +

Chronic Myeloid Leukemia +

Lymphoblastic Lymphoma +

Lymphoplasmacytic Lymphoma +

Mixed Phenotype Acute Leukemia, B/Myeloid, NOS +

Mixed Phenotype Acute Leukemia, T/Myeloid, NOS +

Peripheral T-Cell Lymphoma +

Primary Cutaneous T-Cell Non-Hodgkin Lymphoma +

Secondary Acute Myeloid Leukemia +

Splenic Marginal Zone Lymphoma +

T-Cell Acute Lymphoblastic Leukemia +

T-Cell Lymphoblastic Lymphoma +

Therapy-Related Acute Myeloid Leukemia +

Waldenstrom Macroglobulinemia +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.