Overview

Location [1]
19q13.31
Protein [2]
DNA repair protein XRCC1
Synonyms [1]
RCC, SCAR26

XRCC1 is altered in 1.74% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, melanoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

XRCC1 GENIE Cases - Top Diseases

The most common alterations in XRCC1 are XRCC1 Mutation (1.52%), XRCC1 Fusion (0.15%), XRCC1 R580W (0.08%), XRCC1 P141S (0.03%), and XRCC1 R109C (0.03%) [3].

XRCC1 GENIE Cases - Top Alterations

Significance of XRCC1 in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Prostate Carcinoma +

Ovarian Carcinoma +

Breast Carcinoma +

Cervical Carcinoma +

Colorectal Carcinoma +

Primary Peritoneal Carcinoma +

Endometrial Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Non-Small Cell Lung Carcinoma +

Non-Hodgkin Lymphoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Fallopian Tube Carcinoma +

Vaginal Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Malignant Ovarian Epithelial Tumor +

Bladder Urothelial Carcinoma +

Urothelial Carcinoma +

Small Cell Lung Carcinoma +

Malignant Intestinal Neoplasm +

Diffuse Large B-Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Cholangiocarcinoma +

Gastrointestinal Stromal Tumor +

Soft Tissue Sarcoma +

Gastric Carcinoma +

Malignant Gastric Neoplasm +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Esophageal Carcinoma +

Malignant Small Intestinal Neoplasm +

Malignant Esophagogastric Neoplasm +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

Mantle Cell Lymphoma +

Penile Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.