Location [1]
Protein [2]
DNA repair protein XRCC1
Synonyms [1]

XRCC1 is altered in 1.44% of all cancers with colorectal adenocarcinoma, non-small cell lung carcinoma, ovarian neoplasm, breast carcinoma, and malignant glioma having the greatest prevalence of alterations [3].

XRCC1 GENIE Cases - Top Diseases

The most common alterations in XRCC1 are XRCC1 Mutation (0.19%), XRCC1 R580W (0.01%), XRCC1 Amplification (0.00%), XRCC1 G422R (0.00%), and XRCC1 P141S (0.00%) [3].

XRCC1 GENIE Cases - Top Alterations

Significance of XRCC1 in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Breast Carcinoma +

Prostate Carcinoma +

Ovarian Carcinoma +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Cervical Carcinoma +

Small Cell Lung Carcinoma +

Gastric Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Cholangiocarcinoma +

Vaginal Carcinoma +

High Grade Ovarian Serous Adenocarcinoma +

Diffuse Large B-Cell Lymphoma +

Urothelial Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Non-Small Cell Lung Carcinoma +

Lung Adenocarcinoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Anal Carcinoma +

Clear Cell Renal Cell Carcinoma +

Endometrial Carcinoma +

Fallopian Tube Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Mantle Cell Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Mesothelioma +

Penile Carcinoma +

Peritoneal Carcinoma +

Soft Tissue Sarcoma +

Uveal Melanoma +

Vulvar Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.