The intra- and intercellular architecture of tumor cells plays an important role in cellular processes. The tumor cell has polarity defined by the presence of specific cytoskeletal features. The coordinated function of the cytoskeletal and architectural features of the cell allow regulation of processes within and across the cell. For example, nutrients and chemical mediators can be passed through an individual cell from the apical membrane to the basolateral membrane or passed in between the cell via cell-cell junctions at the basolateral membrane. [1]

Figure 1. Simplified schematic of a polarized epithelial cell showing the apical membrane at the top of the cell and the basolateral membrane at the sides of the cell.

Pathways upstream of cellular architecture and microenvironment pathway:
Drug categories targeting cellular architecture and microenvironment pathway:


1. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.