Location [1]
Cellular architecture and microenvironment, MAP kinase signaling
Protein [2]
Proto-oncogene tyrosine-protein kinase Src
Synonyms [1]
ASV, c-SRC, p60-Src, SRC1, THC6

SRC proto-oncogene, non-receptor tyrosine kinase (SRC) is a gene that encodes a protein that functions in the regulation of embryonic development and cell growth. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

SRC is altered in 1.07% of all cancers with colon adenocarcinoma, breast invasive ductal carcinoma, lung adenocarcinoma, rectal adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].

SRC GENIE Cases - Top Diseases

The most common alterations in SRC are SRC Mutation (0.59%), SRC Amplification (0.60%), SRC Loss (0.07%), SRC E527K (0.02%), and SRC R271W (0.09%) [3].

SRC GENIE Cases - Top Alterations

Significance of SRC in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Melanoma +

Non-Hodgkin Lymphoma +

Glioma +

Multiple Myeloma +

Low Grade Glioma +

Ovarian Carcinoma +

Thyroid Gland Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Colorectal Carcinoma +

Endometrial Carcinoma +

Cutaneous Melanoma +

Chronic Myelomonocytic Leukemia +

Malignant Peripheral Nerve Sheath Tumor +

Ganglioglioma +

Squamous Cell Lung Carcinoma +

Pancreatic Carcinoma +

Diffuse Glioma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Astrocytic Tumor +

Neuronal And Mixed Neuronal-Glial Tumors +

Breast Carcinoma +

Myelodysplastic Syndromes +

Renal Cell Carcinoma +

Hepatocellular Carcinoma +

Soft Tissue Sarcoma +

B-Cell Non-Hodgkin Lymphoma +

Acute Myeloid Leukemia +

Dysembryoplastic Neuroepithelial Tumor +

Embryonal Rhabdomyosarcoma +

Gangliocytoma +

Low-Grade Neuroepithelial Tumor, NOS +

Neuroblastoma +

Neurofibromatosis Type 1 +

Pilocytic Astrocytoma +

Pilomyxoid Astrocytoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Rhabdoid Tumor +

Schwannoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.