Overview

Location [1]
20q11.23
Pathways
MAP kinase signaling, Cellular architecture and microenvironment
Protein [2]
Proto-oncogene tyrosine-protein kinase Src
Synonyms [1]
ASV, SRC1, c-SRC, p60-Src, THC6

SRC proto-oncogene, non-receptor tyrosine kinase (SRC) is a gene that encodes a protein that functions in the regulation of embryonic development and cell growth. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

SRC is altered in 0.92% of all cancers with colon adenocarcinoma, breast invasive ductal carcinoma, lung adenocarcinoma, rectal adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

SRC GENIE Cases - Top Diseases

The most common alterations in SRC are SRC Mutation (0.67%), SRC Amplification (0.48%), SRC Loss (0.03%), SRC A237T (0.01%), and SRC T292N (0.01%) [3].

SRC GENIE Cases - Top Alterations

Significance of SRC in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Melanoma +

Non-Hodgkin Lymphoma +

Glioma +

Histiocytic And Dendritic Cell Neoplasm +

Multiple Myeloma +

Neuroblastoma +

Ovarian Carcinoma +

Colorectal Carcinoma +

Endometrial Carcinoma +

Cutaneous Melanoma +

Squamous Cell Lung Carcinoma +

Breast Carcinoma +

Pancreatic Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Embryonal Rhabdomyosarcoma +

Hepatocellular Carcinoma +

Low Grade Glioma +

Malignant Peripheral Nerve Sheath Tumor +

Neurofibromatosis Type 1 +

Poorly Differentiated Thyroid Gland Carcinoma +

Renal Cell Carcinoma +

Rhabdoid Tumor +

Schwannoma +

Soft Tissue Sarcoma +

Thyroid Gland Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.