Overview

Location [1]
20q11.23
Pathways
Cellular architecture and microenvironment, MAP kinase signaling
Synonyms [1]
THC6, SRC1, ASV, c-SRC, p60-Src

SRC proto-oncogene, non-receptor tyrosine kinase (SRC) is a gene that encodes a protein that functions in the regulation of embryonic development and cell growth. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

Significance of SRC in Diseases

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Melanoma +

Non-Hodgkin Lymphoma +

Glioma +

Histiocytic And Dendritic Cell Neoplasm +

Low Grade Glioma +

Multiple Myeloma +

Ovarian Carcinoma +

Thyroid Gland Carcinoma +

Acute Myeloid Leukemia +

Astrocytic Tumor +

B-Cell Non-Hodgkin Lymphoma +

Breast Carcinoma +

Chronic Myelomonocytic Leukemia +

Colorectal Carcinoma +

Cutaneous Melanoma +

Diffuse Glioma +

Dysembryoplastic Neuroepithelial Tumor +

Embryonal Rhabdomyosarcoma +

Endometrial Carcinoma +

Gangliocytoma +

Ganglioglioma +

Hepatocellular Carcinoma +

Low-Grade Neuroepithelial Tumor, NOS +

Malignant Peripheral Nerve Sheath Tumor +

Myelodysplastic Syndromes +

Neuroblastoma +

Neurofibromatosis Type 1 +

Neuronal And Mixed Neuronal-Glial Tumors +

Pancreatic Carcinoma +

Pilocytic Astrocytoma +

Pilomyxoid Astrocytoma +

Poorly Differentiated Thyroid Gland Carcinoma +

Renal Cell Carcinoma +

Rhabdoid Tumor +

Schwannoma +

Soft Tissue Sarcoma +

Squamous Cell Lung Carcinoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.