Overview

Receptor tyrosine kinase cell signaling pathways regulate a variety of cellular processes including cell growth, proliferation, differentiation, survival, gene transcription, metabolic regulation, and others. Receptor tyrosine kinase signaling pathways are activated by the binding of a ligand, such as a growth factor, to the receptor tyrosine kinase. Receptor tyrosine kinase signaling pathways are inhibited by complex negative feedback loops which function to attenuate the activated receptor signaling. [1]

Figure 1. Binding of a growth factor (e.g., EGF, HGF) to a receptor tyrosine kinase activates the receptor tyrosine kinase and typically causes the dimerization of the two receptor monomers. The receptors are activated by phosphorylation within their kinase domains. Once the receptor is turned on, numerous downstream pathways are activated including MAP kinase signaling, JAK/STAT signaling, and PI3K/AKT1/MTOR signaling. Specific nodes in the pathway that are therapeutically actionable are noted.

References

1. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.